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Aminocoumarin

Aminoglycoside

Antimetabolite

Beta-lactam

Bisindole

Cyclodipeptide

Isonitrile

Lincoside

NRPS-independent siderophore

Nucleoside

Phosphonate

Regulatory

RiPP

Nonribosomal peptide

Polyketide

Type II polyketide

Other

Cluster 23

Polyketide/nonribosomal peptide
From search #20190318-1629-590782499
Sequence: DS999644.1.fasta

Biosynthetic assembly:

orf_6321 KSiMeMDHKRTCOrnTE

Cluster:

orf_6321

Legend:

Aminocoumarin

Aminoglycoside

Antimetabolite

Beta-lactam

Bisindole

Cyclodipeptide

CDPS active site

Deoxysugar

Isonitrile

Lincoside

Siderophore

Nucleoside

Phosphonate

Regulatory

Resistance

RiPP

Cleaved propeptide

Nonribosomal peptide

Polyketide

Hybrid

Type II polyketide

Tailoring

Bacteriocin

Other

Predicted cluster product:

Combinatorial structure library: TXT or open in browser

GNP library: TXT

Combinatorial data evaluated:

  • Open reading frame permutations: 1
    (maximum 500)
  • Subgraph combinations: 1
  • Total combinatorial plans: 1 (maximum 1,000)
  • Scaffolds generated: 1 (maximum 50)

Downloads:

Genomic cluster sequence: FASTA
Biosynthetic open reading frames: FASTA
All cluster open reading frames: FASTA
JSON report: JSON

Analysis

orf_6321

Domain Start End Score
Ketosynthase+ 13 439 579.8
1_Strep-ZP-06279092-i_iterative_ 835.0
1_ikarugamycin_iterative_Mal 742.0
1_HSAF-ABL86391-i_iterative_ 733.0
1_HSAF_iterative_Mal 732.0
1_frontalamide_iterative_MaI 710.0
1_chondrochloren_KSQ_MeM 421.0
2_chondrochloren_cis_MeM 420.0
3_stigmatellin_cis_Mal 417.0
1_chivosazole_cis_Mal 415.0
1_jamaicamide_cis_Mal 414.0
Acyltransferase+ 551 847 336.0
Methylmalonyl-CoA 4 273 384.6
Methoxymalonyl-CoA 4 273 317.5
Malonyl-CoA 3 273 305.5
Methylmalonyl-CoA 4 273 301.3
Ethylmalonyl-CoA 4 273 271.2
Ethylmalonyl-CoA 4 273 267.5
Isobuteryl-CoA 3 273 267.2
Methylmalonyl-CoA 4 273 252.6
2-Methylbuteryl-CoA 4 273 234.9
Methylmalonyl-CoA 188 273 85.7
Dehydratase+ 909 1068 144.8
Active dehydratase, cluster 71 2 159 195.1
Active dehydratase, cluster 17 2 159 126.2
Active dehydratase, cluster 36 2 159 120.4
Active dehydratase, cluster 25 2 159 97.2
Active dehydratase, cluster 22 2 159 86.7
Inactive dehydratase, cluster 8 2 159 83.6
Active dehydratase, cluster 23 3 159 83.1
Active dehydratase, cluster 20 2 159 82.9
Active dehydratase, cluster 21 2 159 80.3
Active dehydratase, cluster 10 124 159 1.7
Ketoreductase+ 1447 1658 164.0
Active ketoreductase, cluster 4 2 195 266.3
Active ketoreductase, cluster 2 2 195 189.0
Active ketoreductase, cluster 12 2 195 168.7
Inactive ketoreductase, cluster 1 2 195 152.5
Inactive ketoreductase, cluster 2 2 194 140.5
Active ketoreductase, cluster 3 2 195 136.7
Active ketoreductase, cluster 1 43 195 124.9
Active ketoreductase, cluster 6 2 195 113.5
Active ketoreductase, cluster 16 2 188 84.5
Inactive ketoreductase, cluster 3 2 57 9.8
Thiolation 1740 1806 40.9
Condensation+ 1831 2130 217.6
Sare2407_1 447.0
tyroc3_C2_LCL 184.0
bacit3_C5_LCL 184.0
syrin1_C9_LCL 180.0
tyroc3_C3_LCL 180.0
grami2_C4_LCL 175.0
tyroc3_C6_LCL 172.0
surfa4_C3_LCL 171.0
syrin1_C5_LCL 171.0
bacit3_C2_LCL 171.0
Adenylation+ 2303 2733 321.8
Ornithine 28 430 496.5
Lysine 28 430 344.5
2,4-diamino-butyric acid 28 430 341.4
Tryptophan 28 430 314.0
Serine 28 430 313.2
Phenylalanine 28 430 313.0
Arginine 130 430 291.9
Leucine 28 430 283.1
Alanine 28 430 274.4
α-ketoisocaproate 4 430 109.6
Thioesterase 2895 3091 84.0

Detection: predicted by Prodigal
Start: 7242915 | End: 7252356 | Frame: +

Sequence: show MADANSRALRDKVAIIGMGCRLPGGASDHRTFWRNLVAGKDCITPTPPDRYDVRTLGSRFRDKPGRLVGGRGGYIDGFDEFDPAFFGISPREADHMDPQQRKLLEVAWEALEDGGQRPADLAGSDVAVYVGAFTLDYKILQFADLGFTSLAAHTATGTMMTMVSNRISYCFDFRGPSLSVDTACSSSLVAVHLACQALHNGETDLALAGGTLLHMAPQYTVAETKGGFLSPGGRSRTFDAAADGYVRAEGVGLVALKRLDDAVRDGDRIHAVILASGVNQDGHTNGITVPNPDAQVDLIRRVCAEAGITPGDLQYMEAHGTSTPVGDPIEANALARALAVGRAPGARAYVGSVKTNIGHTESAAGIAGLIKTVLSIEHRTIPPHINLENLNPAIDPATLPYEIPTRPTDWPAHQGPARAGVNSFGFGGTNAHVVLEEAPPPLPPGPGKAAASGGRRWSILPLSARRPDALPEMAAGIRGELAGDNGPAVTLDDLGHTLAHRRQHLPERLAVVHSSRASLDEALAAHERGEPHPRVVHGRARDAADRKLVWVFTGMGPQWWGMGRQLLEEEPVFRDAVTACDRALREFADWSLVEELTAGESVSRMSETWLAQPANFAVQVGLAALWRSHGVRPDAVVGHSTGEIAAFHAAGVYSLRDAARIAVHRSRLQQTLAGTGTMLAVSLSEDEAERRVRPYSDRVSVAAVNSPTAITLAGDEAALTLLAEELRAEQQFAKFLTVEVPYHSVGMERIKDELLTELAPLEPRAAQVPLYLTGVEGTARGEELDAAYWWKNVRDRVRFRSAIDRVADDGHRVFLEIGPHPVLGHAIRECLEAGGRSALTLPSIRRKEDETERFAASLGTLHTLGVPIDWDLLQPTGRPVTLPRHPFRRDRHWTEPRPVAQVRLGHRDHPLLGRRTDATEPTWQARLDTEALPYLADHRIQDTVVFPAAGYLEMAAQAVLRLTGGTTAVLADIDLRKALFLPDDEDRTVEVSLSLENAAFTIASPAGEDGERAVHASGIVRTGQRRRTAAPLDAPAIRARARRHLAGPDCYTALAALGYHYGPAFQAVEEVWIGADEVLARIRPPRAIGEGAAGHHLHPVLLDACFQTLLTPLIPANPEDPAPAGGIRLPLSLDEVALEPVGDRPFWAHATLLPADTDTTLGNIALYTDDGTPLGRIEGFRAADVEKAATAVARTTIDSWLAEPVWTDCPPLPAEDTGTPPRDVSWLLLADTGGLADAFAALADARGERCRLVRRGAAYTASADGRTSTVDPASDADLRRLFADLDRDGGPFRGTVLHLWNLDAPALASCDRTALGDHTGAGAYSLIVLARLLSARGAGGRLHIVTRGAQPALPGEAPEPLGAPAWGIGRVLRHQELTDHPGKLIDLDPRRHPGPDGDRAEAEALLAEALSDDEAEIALRDGGRRTGRLRPAESLTRPLPPRLRADGSYLVTGAFGALGRLLCRTLVRRGARRIVLVGRTPVPPREKWAGTDPATAEGRAVALLRELETLGAHPVPATFDITDEDALTGWLDAHRRSGAPPVRGVFHLAGQVRDTLVADLDRAAFDAVHGPKTVGAHLLHRHLRDEPLEHFVLFASIASLLTTAGQTNYAAGNAFLDALAHHRRAQGLPALSLDWGPWATGMIEELGLADHYLNSRGMSSLSPEAGMAVLERVIGQDHAQLVVATVVDWPVFLAWYPSPPPLVADLAAAAAPPADTASGNGFLDTFRTAGEEARRALVTERFAALAATVLRTGADRIDPATGLGELGLDSLLAMELRARIHAELGVALPVVALLSGSPTGELADRLHDGLTALASADDPGRADGTVQLHTDERKYPLTQNQKALWFLKHLNPDGYAYNIGGAVEVNVALEPDLMFEAVRRLIARHPALRTNFLLVDGQAVQQVSEEARTDLALFDVRGEDWETIHATIVEEYRKPYDLAHDPLIRFRLFKRGPDRWIIMKAVHHIVSDAISTFTFIEELLAVYEALRRNQEHRLPPVEARYLDFLNQQNAFLAGPEAAGMLDYWRSHLPAEVPLLDLPVDKPRPAVQTHNGASEFFVLDDALSARVHALARTHGVTPFMVLLSAYYLLLHRYSGQDHIVVGSPVTGRTRQDFASVYGYFVNPLPLHADLSDDPTVAELLQQVRRTVLGGLDNQEYPFVLLVEELGLQHDPSRSAVFQAMFILLTHKVATEQYGYRLEYIELPEEEGQFDITLSAYEDESEGRFHCVFKYNTDLFLPETMRRMAAHYTRLLDRMTRAPGDRPASRLAMLGDRERERLVGEWSRPALPYAGHRDDDPFTPVHALIARTAAEHPEAVAVSTPSPHGGAHRLTYADLERRAADTAARLRTLGIGEGSVVVLCLDKSPELIVALLAVLKAGAAYLPIRPDQPADRLAHLVSATGAELVLVADDAGPGATDNAGPGATGTTGATGIDAALTVPTLTLAALVRTEPHPDGPAAQVAPDSPAYVITTSGSTGRPKAVRVSHRNLASAHAAWRQAYRLDTDVTTHLQMAEPSFDVFTGDLVRALCSGGTLVLADRDLLFDTTRLYRTMRQERVDCAEFVPAVIRGLMDHCAREGLRLDFLRLLVVGSDAWSVGEYRGLAELCGPGTRLVNSYGLTEATIDSAYFEGPVDDLEPGAMVPIGRPLPNSTLHILDAHGEPVPPGVPGELWIGGRGVALGYAGDPEQTGERFVTRTLSGAADARPERLYRTGDIARWDAHGRVHLLGRTDGQIKLRGHRIEIGEIEAHLAQWPPLARAVVTVRTDTGGDAALCAYCVPEAGAALDVRALRRHLARSLPSYMIPSHFTELPALPLTANGKVDTAALPALRAEAGDRPYEEPVTLYEVSVARHWKTLLGREQIGLGDDFFELGGSSIKLIELLHHLRTEFGVGVPVSRLYQVTTLHGMAATVQDVLLGASADELPSLTFNAGQHPALFCFPPAGGHGLVYRGLAAQLPDHRVVGFNYLPGDDKVARYADLIEADQPEGPCLLLGYSLGGNLAFETAKELERRGHRVDHVVILDSRRILTAYEPDASGIAAFEAELADHVRKHTGSDAVTRETLAHAAEYLAFCGRTPNTGTVAATVTVITDEEKALYAAGEHGTWHGSSTGATAVLRGSGVHADMLDAKHLARNARLVRSVIAGEAPHDR (hide)

Domain analysis:

Biosynthetic assembly:

KSiMeMDHKRTCOrnTE