Terms of Service
BY USING PRISM YOU CERTIFY THAT YOU ARE AN ACADEMIC OR NOT-FOR-PROFIT END USER (AS DEFINED BELOW) AND YOU AGREE TO BE BOUND BY THE TERMS OF THIS EULA, AS THESE MAY BE UPDATED FROM TIME TO TIME.
IF YOU DO NOT AGREE TO THESE TERMS, DO NOT USE PRISM AND WHEN PRESENTED WITH THE OPTION TO “AGREE” OR “DECLINE” THE TERMS OF THIS EULA, CLICK “DECLINE”.
March 19, 2019
PRISM 4 is up and running! The newest version of the PRISM web application contains hundreds of new hidden Markov models and virtual tailoring reactions, bringing complete chemical structure prediction to seven new classes of secondary metabolites. We've also optimized some key bottlenecks in PRISM, meaning your jobs will run around ~10× faster, for an average genome. Look out for a complete description of these changes in the near future.
Due to legal requirements, we had to make some changes in how you submit jobs. Please read through the EULA for complete details. Namely, we now require valid email addresses to run PRISM on the web. You will receive an email containing a link to your results, so please use an email address you have access to.
December 31, 2016
PRISM 3 is online now. We're rolling out some big changes with PRISM 3. The biggest change is that the chemical structure prediction engine within PRISM has been completely rewritten. Instead of modelling natural product structures as linear permutations of monomers, PRISM now models them as chemical graphs. This allowed us to extend structure prediction to four new natural product classes—aminocoumarins, antimetabolites, bisindoles, and phosphonate-containing natural products. We've also added cluster detection, but not structure prediction, for eleven new classes (aryl polyenes, butyrolactones, ectoines, furans, homoserine lactones, ladderanes, melanins, phenazines, phosphoglycolipids, resorcinols, and stilbenes). Finally, PRISM 3 also features improved sequence and ORF detection, a more user-friendly interface, a more detailed Help page with sample output, and improved JSON and HTML output.
October 4, 2016
You may notice some changes to PRISM associated with the public release of the PRISM 2.1.5 web application. We've rewritten PRISM to run over a 300-core server grid. This means PRISM will no longer give detailed updates on the status of your job every second. However, jobs should run much faster, especially during times when PRISM is in high demand. We hope you like it.
In other news, the RiPP-PRISM paper is now published. RiPP-PRISM is integrated into the publicly available PRISM web application: users have the option of enabling or disabling RiPP cluster analysis and prediction.